To clarify, the latest release did not introduce multisite support. Multisite support has been implemented since 2017. See the 2.2.3 release notes for multisite support, and the 2.4.0 release notes for network-active multisite support.
The latest patch 5.0.11 resolves an issue with installing the plugin on distinct sites in a network installation, as opposed to network-activating the plugin across all sites.
You bring up a valid point: I have put out too little information about this. I will write an in depth how-to guide on this topic, detailing all the different choices and trade-offs.
I will post the link here when it’s ready, hopefully later today.
There are no changes needed in your bitcoin.conf file. You can simply point as many coin adapters as you want to the same wallet You could use the same coin adapter settings in two different installations, whether they are on the same network or not, but with some caveats. See the article I just posted for more details: