Yes, and additionally, consider this:
Commissions are always accumulated to vendors in the store’s default currency. The end customer could have paid for the cart with cryptocurrencies, or with any other method, such as USD or EUR, and via PayPal, Stripe, or via any other gateway compatible with WooCommerce.
When you say that you pay commissions out as crypto, this means that you have converted any such amounts to the payout crypto. The plugin does the calculation for you. As an admin, you just make sure that enough funds are available. If there are not enough funds for a payout to proceed, the payout can be retried later when you put in the funds in the admin account.